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Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection

Saito, T., Shimizu, Y., Tsukakoshi, K., Abe, K., Lee, J.H., Ueno, K., Asano, R., Jones, B.V., Yamada, T., Nakano, T., Tong, J., Asami, H., Harada, K., Hashimoto, H., Sode, K., Toyo’oka, T..Todoroki, K., Ikebukuro, K. Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection, Biosens. Bioelectron., 203, 114027. doi: 10.1016/j.bios.2022.114027., 2022

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