臼井　達哉

Professional Career

経歴

2011/04/01 - 2013/03/31 : 日本学術振興会　特別研究員(DC1・農学)
2013/04/01 - 2013/10/31 : 日本学術振興会　特別研究員(PD・農学)
2013/11/01 - 2017/08/31 : 山口大学　共同獣医学部・獣医毒性学　助教
2015/04/01 - 2015/09/30 : スタンフォード大学　医学部　客員教員
2017/09/01 - 2022/08/31 : 東京農工大学　農学研究院　動物生命科学部門　特任講師
2022/09/01 - 現在 : 東京農工大学　農学研究院　動物生命科学部門　准教授

Academic Degrees

学位

2013/03　博士（獣医学）　北里大学

Research Interests

キーワード

獣医薬理、がん、三次元培養、生活習慣病

Publications

論文

• Elbadawy, M., Saito, N., Kato, Y., Hayashi, K., Abugomaa, A., Kobayashi, M., Yoshida, T., Shibutani, M., Kaneda, M., Yamawaki, H., Sasaki, K., Usui, T., Omatsu, T. Establishment of a bat lung organoid culture model for studying bat-derived infectious diseases Establishment of an experimental model of canine apocrine gland anal sac adenocarcinoma organoid culture using a three-dimensional culture method. Scientific Reports 15: 61084035, 2025.

• Nagashima, Y., Yamamoto, H., Elbadawy, M, Ishihara, Y., Tsurukami, I., Abugomaa, A., Kaneda, M., Yamawaki, H,, Usui, T., Sasaki, K. Establishment of an experimental model of canine apocrine gland anal sac adenocarcinoma organoid culture using a three-dimensional culture method. Scientific Reports 15: 6108, 2025.

• Shinohara, Y., Elbadawy, M., Liu, Y., Yamanaka, M., Yamamoto, H., Sato, Y., Abugomaa, A., Ishihara, Y., Usui, T., Sasaki, K. Anticancer activity of chaga and notoginseng against dog bladder cancer organoids. J Vet Med Sci. 87 (2), 232-240, https://doi.org/10.1292/jvms.24-0258,

• Kobayashi, M., Usui, T., Elbadawy, M., Kigata, T., Kaneda, M., Murakami, T., Kozono, Takuma., Ito, Yoshiyuki., Shibutani, M., Yoshida, T. Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis. International Journal of Molecular Sciences. 25: 12706, 2024.

• Kobayashi, Y., Hashizume, H, Takiguchi S., Ji, J., Kawano, R., Koiwai, K., Yamamoto, H., Elbadawy, M., Omatsu, T., Abugomaa, A., Kaneda, M., Usui, T., Sasaki, K. A microfluidics platform for simultaneous evaluation of sensitivity and side effects of anti-cancer drugs using a three-dimensional culture method. Scientific Reports 15: 39, 2025.

• Liu, Y., Elbadawy, M., Yamamoto, H., Abugomaa, A., Ishihara, Y., Kaneda, M., Usui, T., Sasaki, K. Salinomycin induces apoptosis and potentiates the antitumor effect of doxorubicin against feline mammary tumor 2.5D organoids. J Vet Med Sci. 86: 1256-1264. 2024.

• Ting-Wei Y, Yamamoto H, Morita S, Fukushima R, Elbadawy M, Usui T, Sasaki K. Comparative pharmacokinetics of tyrosine kinase inhibitor, lapatinib, in dogs and cats following single oral administration. Jornal of Veterinary Medical Science, 86(3):317-321, 2024.

• Elbadawy M, Tanabe K, Yamamoto H, Ishihara Y, Mochizuki M, Abugomaa A, Yamawaki, H, Kaneda, M, Usui, T, Sasaki, K. Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids. Frontiers in Pharmacology, 14. 1243258. 2023

• Nabeta R, Kanaya A, Elbadawy M, Usui T, Furuya T, Suzuki K, Uchide T. Chemosensitivity of Three Patient-derived Primary Cultures of Canine Pericardial Mesothelioma by Single agent and Combination Treatment. Frontiers in Veterinary Science, 10, 1267359. 2023.

• Hussein M, Eman A, Usui T, Ishihara Y, Yoshida T, Kobayashi M, Sasaki K, Ma D, Yairo A, Mandour A, Hendawy H, Doghish A, Mohammed O, Takahashi K, Tanaka R. Adipose Stem Cell-Seeded Decellularized Porcine Pericardium: A Promising Functional Biomaterial to Synergistically Restore the Cardiac Functions Post-Myocardial Infarction. Veterinary Science. 10, 10.3390. 2023.

• Ameen A. Salahudeen,, Jose A. Seoane, Kanako Yuki, Amanda T. Mah, Amber R. Smith, Kevin Kolahi, Sean M. De la O, Daniel J. Hart, Jie Ding, Zhicheng Ma, Sammy A. Barkal, Navika D. Shukla,Chuck H. Zhang, Michael A. Cantrell, Arpit Batish, Usui T, David Root, William Hahn, Christina Curtis,and Calvin J. Kuo. Functional screening of amplification outlier oncogenes in organoid models of early tumorigenesis. Cell Reports,42(11):113355, 2023.

• Hussein M, Eman A, Kaneda M, Shimada K, Nakazawa Y, Usui T, Elbadawy M, Ishihara Y, Hirose M, Kamei Y, Ahmed S, Hesham A, El-Malaa A, Walla A, Taknaka R. Comparison of Bovine- and Porcine-Derived Decellularized Biomaterials: Promising Platforms for Tissue Engineering Applications. Pharmaceutics. 15, 1906. 2023.

• Sato Y, Elbadawy M, Suzuki K, Tsunedomi R, Nagano H, Ishihara Y, Yamamoto H, Azakami D, Uchide T, Fukushima R, Tanaka R, Yoshida T, Mori T, Abugomaa A, Kaneda M, Yamawaki H, Shinohara Y, Aboubakr M, El-Asrag, M, Usui, T, Sasaki, K. Derivation of a new model of lung adenocarcinoma using canine lung cancer organoids for translational research in pulmonary medicine. Biomedicine & Pharmacotherapy, 165: 115079. 2023

• Abugomaa A, Elbadawy M, Ishihara Y, Yamamoto H, Kaneda, M, Yamawaki, H, Shinohara Y, Usui, T, Sasaki, K. Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids, Frontiers in Pharmacology, 14:1159516.2023

• Sato Y, Elbadawy M, Suzuki K, Tsunedomi R, Nagano H, Ishihara Y, Yamamoto H, Azakami D, Kaneda M, Ishihara, Y, Sato, Y, Yamawaki, H, Kaneda, M, Usui, T, Sasaki, K. Establishment of an experimental model of canine malignant mesothelioma organoid culture using a three-dimensional culture method. Biomedicine & Pharmacotherapy162: 114651. 2023

• Abugomaa A, Elbadawy M, Yamamoto H, Ayame, H, Ishihara, Y, Sato, Y, Yamawaki, H, Kaneda, M, Usui, T, Sasaki, K. Establishment of a direct 2.5D organoid culture model using companion animal cancer tissues. Biomedicine & Pharmacotherapy. 154:113597. 2022.

• Shinohara Y, Elbadawy M, Yamanaka M, Yamamoto H, Abugomaa A, Usui T, Sasaki K. Effect of the liquid form of traditional Chinese medicine, Hozen-S, on gastric motility in dogs. Journal of Veterinary Medical Science. 84:841-846.2022.

• Yoshida, T., Kobayashi, M., Uomoto, S., Ohshima, K., Hara, E., Katoh, Y., Takahashi, N., Harada, T., Usui, T., Elbadawy, M., Shibutani, M.: The potential of organoids in toxicologic pathology: role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment. Journal of Toxicologic Pathology (J. Toxicol. Pathol.) 35(3): 225–235, 2022.

• Elbadawy M, Fujisaka K, Yamamoto H, Tsunedomi R, Nagano H, Ayame H, Ishihara Y, Mori T, Azakami D, Uchide T, Fukushima R, Abugomaa A, Kaneda M, Hideyuki M Yamawaki, Shinohara Y, Omatsu T, Mizutani T, Usui T, Sasaki K. Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture method. Biomedicine & Pharmacotherapy. 151:113105. 2022.

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim CK, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus. Int J Mol Sci. 2021 Oct 5;22(19):10763

• Endo T, Nakagomi Y, Kawaguchi E, Hayakawa ESH, Vu HN, Takemae H, Shinohara Y, Yang D, Usui T, Mizutani T, Nakao Y, Furuya T. Anti-malarial activity in a Chinese herbal supplement containing Inonotus obliquus and Panax notoginseng. Parasitol Int. 2022 Dec 18;87:102532. doi: 10.1016/j.parint.2021.102532. Epub ahead of print. PMID: 34933121.

• Elbadawy M, Kato Y, Saito N, Hayashi K, Abugomaa A, Kobayashi M, Yoshida T, Shibutani M, Kaneda M, Yamawaki H, Mizutani T, Lim C-K, Saijo M, Sasaki K, Usui T, Omatsu T. Establishment of Intestinal Organoid from Rousettus leschenaultii and the Susceptibility to Bat-associated Viruses, SARS-CoV-2 and Pteropine orthoreovirus. International Journal of Molecular Sciences, 22 (19) 10763, 2021
• Yamamoto H, Elbadawy M, Fujisaka K, Sato Y, Ohmori T, Shinohara Y, Hatano Y, Kobayashi D, Gomyo A, Sudo Y, Azakami D, Uchide T, Fukushima R, Morita S, Abugomaa A, Yamawaki H, Kaneda M, Usui T, Sasaki K. Evaluation of the Safety and Feasibility of Apheresis in Dogs: For Application in Metastatic Cancer Research. Animals 11 (10) :2770, 2021
• Elbadawy, M., Hayashi, K., Ayame, H., Ishihara, Y., Abugomaa, A., Shibutani, M., Hayashi, S. M., Hazama, S., Takenouchi, H., Nakajima, M., Tsunedomi, R., Suzuki, N., Nagano, H., Shinohara, Y., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids. Biomed. Pharmacother. 142, 112043, 2021. https://doi.org/10.1016/j.biopha.2021.112043
• Elbadawy, M., Sato, Y., Mori, T., Goto, Y., Hayashi, K., Yamanaka, M., Azakami, D., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Kobayashi, M., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Anti-tumor effect of trametinib in bladder cancer organoid and the underlying mechanism. Cancer Biol. Ther. 22(5-6), 357–371, 2021. https://doi.org/10.1080/15384047.2021.1919004
• Yamashita, R., Takahashi, Y., Takashima, K., Okano, H., Ojiro, R., Tang, Q., Kikuchi, S., Kobayashi, M., Ogawa, B., Jin, M., Kubota, R., Ikarashi, Y., Yoshida, T., Shibutani, M.: Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats. Toxicology 456: 152782, 2021.
• Abugomaa, A., Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Mori, T., Uchide, T., Azakami, D., Fukushima, R., Yoshida, T., Shibutani, M., Yamashita, R., Kobayashi, M., Yamawaki, H., Shinohara, Y., Kaneda, M., Usui, T., Sasaki, K., Establishment of 2.5D organoid culture model using 3D bladder cancer organoid culture. Scientific Reports, 10(1), 9393, 2020.
• Elbadawy, M., Yamanaka, M., Goto, Y., Hayashi, K., Tsunedomi, R., Hazama, S., Nagano, H., Yoshida, T., Shibutani, M., Ichikawa, R., Nakahara, J., Omatsu, T., Mizutani, T., Katayama, Y., Shinohara, Y., Abugomaa, A., Kaneda, M., Yamawaki, H., Usui, T., Sasaki, K.: Efficacy of primary liver organoid culture from different stages of non-alcoholic steatohepatitis (NASH) mouse model. Biomaterials 237:119823, 2020
• Elbadawy, M., Usui, T., Mori, T., Tsunedomi, R., Hazama, S., Nabeta, R., Uchide, T., Fukushima, R., Yoshida, T., Shibutani, M., Tanaka, T., Masuda, S., Okada, R., Ichikawa, R., Omatsu, T., Mizutani, T., Katayama, Y., Noguchi, S., Iwai, S., Nakagawa, T., Shinohara, Y., Kaneda, M., Yamawaki, H., Sasaki, K. Establishment of a novel experimental model for muscle-invasive bladder cancer using a dog bladder cancer organoid culture.  Cancer Science (Cancer Sci.). 110(9):2806-2821, 2019.
• Nabeta R, Nakagawa Y, Chiba S, Xiantao H, Usui T, Suzuki K, Furuya T, Fukushima R, Uchide T. Pericardial Mesothelioma in a Dog: The Feasibility of Ultrasonography in Monitoring Tumor Progression. Front Vet Sci. 2019 Apr 18;6:121. doi: 10.3389/fvets.2019.00121. eCollection 2019.