永岡　謙太郎

Professional Career

経歴

2000年4月-2003年3月：日本学術振興会　特別研究員DC1
2003年4月-2004年5月：協和発酵工業株式会社　医薬カンパニー安全性研究所
2004年6月-2007年3月：東京大学大学院　農学生命科学研究科　助手
2007年4月-2011年2月：東京大学大学院　農学生命科学研究科　助教
2009年4月-2011年2月：マサチューセッツ州立大　客員研究員
2009年4月-2011年2月：日本学術振興会海外特別研究員
2011年3月-2014年2月：東京農工大学大学院　農学研究院　助教
2014年3月-2018年12月：東京農工大学大学院　農学研究院　准教授（テニュア取得）
2018年12月-現在：東京農工大学　グローバルイノベーション研究院（農学研究院兼務）　教授（キャリアチャレンジ）

Academic Degrees

学位

2003年 博士（獣医学）東京大学

Research Interests

キーワード

生物進化の過程で、我々哺乳類は乳腺組織を獲得し母乳を作り子に与える「哺育」を繁殖戦略に取り入れ発展してきた。母乳成分は単に子を大きくさせるだけでなく、脳や腸内細菌叢の形成など健常に育たせるためにも重要です。私は、哺乳類を特徴付ける乳腺の役割やその疾病について、様々な動物種との比較を交えながら研究を進めています。

Publications

論文

• Hamabe L, Mandour AS, Shimada K, Uemura A, Yilmaz Z, Nagaoka K, Tanaka R. Role of Two-Dimensional Speckle-Tracking Echocardiography in Early Detection of Left Ventricular Dysfunction in Dogs. Animals. 11(8):2361. 2021.
• Okamoto Y, Ichinohe N, Woo C, Han SY, Kin HH, Ito S, Nakamura C, Kimura J, Nagaoka K, Yamamoto N. Contrasting gut microbiota in captive Eurasian otters (Lutra lutra) by age. Archives of Microbiology, 10.1007/s00203-021-02526-w
• Sovijit WN, Sovijit WE, Pu S, Usuda K, Inoue R, Watanabe G, Yamaguchi H, Nagaoka K. Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice. Neuroscience Research (Neurosci Res). pii: S0168-0102(19),76-82. 2021
• Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M, Khatib H, Imakawa K, Miyamoto A. Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions. Front Genet. 12: 676791. 2021
• Zhang H, Kataoka S, Liu H, Kinukawa M, Uchiyama K, Kambe J, Watanabe G, Jin W, Nagaoka K. L-amino acid oxidase1 in sperm is associated with reproductive performance in male mice and bulls. Biology of Reproduction (Biol Reprod) , 104, 5, 1154-1161, May 2021
• Sovijit, Watcharee; Sovijit, Watcharin; Ishii, Yuriko; Kambe, Jun; Fujita, Tomoyuki; Watanabe, Gen; Yamaguchi, Hirohito; Nagaoka, Kentaro,  Estrogen promotes increased breast cancer cell proliferation and migration through downregulation of CPEB1 expression.  Biochemical and Biophysical Research Communications 534, 1, 2021, 871-876
• Haney Samir, Paul Nyametease, Mohamed Elbadawy, Mohamed Fathi, Ahmed S. Mandour, Faten Radwan, Kentaro Nagaoka, Kazuaki Sasaki, Gen Watanabe, Assessment of correlations and concentrations of salivary and plasma steroids, testicular morphometry, and semen quality in different climatic conditions in goats. Theriogenology 157, 238-244, November 2020
• Kambe, Jun; Sasaki, Yu; Inoue, Ryo; Tomonaga, Shozo; Kinjo, Teruo; Watanabe, Gen; Jin, Wanzhu; Nagaoka, Kentaro, Analysis of infant microbiota composition and the relationship with breast milk components in the Asian elephant (Elephas maximus) at the zoo, Journal of Veterinary Medical Science 87,7, 983-989, 2020
• Shaoxia Pu, Kento Usuda, Kentaro Nagaoka, Andrea Gore, David Crews and Gen Watanabe, The relation between liver damage and reproduction in female Japanese quail (Coturnix Japonica) exposed to high ambient challenge. Poultry Science 99, Issue 9, September 2020, 4586-4597
• Haney Samir, Mohamed A.I. El Sayed, Kentaro Nagaoka, Kazuaki Sasaki, Amal M. Abo El-Maaty, Aly Karen, Mostafa M. Abou-Ahmed, Gen Watanabe, Passive immunization against inhibin increases testicular blood flow in male goats, Theriogenology 147, 15 April 2020, 85-91
• Haney Samir, Paul Nyametease, Mohamed Elbadawy, Kentaro Nagaoka, Kazuaki Sasaki, Gen Watanabe,　Administration of melatonin improves testicular blood flow, circulating hormones, and semen quality in Shiba goats. Theriogenology 2020, 146. 111-119, DOI: 10.1016/j.theriogenology.2020.01.053
• Kambe J, Watcharin S, Makioka-Itaya Y, Inoue R, Watanabe G, Yamaguchi H, Nagaoka K. Heat-killed Enterococcus fecalis (EC-12) supplement alters the expression of neurotransmitter receptor genes in the prefrontal cortex and alleviates anxiety-like behavior in mice. Neuroscience Letter. 720:134753. 2020
• Saab S, Chang SS, Nagaoka K, Hung MC, Yamaguchi H. The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. American Journal of Cancer Research (Am J Cancer Res). 9: 2719-2729
• Yin N, Zhang H, Ye R, Dong M, Lin J, Zhou H, Huang Y, Chen L, Jiang X, Nagaoka K, Zhang C, Jin W. Fluvastatin Sodium Ameliorates Obesity through Brown Fat Activation. International Journal of Molecular Sciences (Int J Mol Sci). 20(7). pii: E1622. 2019