長澤　和夫

Professional Career

経歴

1993年4月 - 2000年12月 : 理化学研究所　研究員
2001年1月 - 2004年3月 : 東京大学分子細胞生物学研究所　助教授
2004年4月- 2009年3月 : 東京農工大学大学院　工学研究科　助教授
2009年4月- 現在 : 東京農工大学大学院　工学研究科　教授

Academic Degrees

学位

1993年　博士（工学）早稲田大学

Research Interests

キーワード

天然有機化合物、グアニジン、ビタミンD、骨、有機分子触媒、テロメラーゼ、イオンチャンネル

Publications

論文

• Tu, A.T.T., Hoshi, K., Ma, Y., Oyama, T., Suzuki, S., Tsukakoshi, K., Nagasawa, K., Ikebukuro, K. & Yamazaki, T., Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides. ACS Chem Biol 17, 1703-1713 (2022)

• Pokhrel, P., Sasaki, S., Hu, C., Karna, D., Pandey, S., Ma, Y., Nagasawa, K., Mao, H. Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex. Anal. Biochem., 649, Article number: 114693, 2022.

• Kaufmann M, Schlingmann K-P, Berezin L, Molin A, Sheftel J, Vig M, Gallagher GC, Nagata A, Masoud SS, Sakamoto R, Nagasawa K, Uesugi M, Kottler ML, Konrad M, Jones G, Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling, J. Bone Miner. Res. 36, 1340-1350, DOI: 10.1002/jbmr.4306. 2021.
• Yasuda, M., Ma, Y., Okabe, S., Wakabayashi, Y., Su, D., Chang, Y.-T., Seimiya, H., Tera, M., Nagasawa, K., Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization, Chemical communication (Chem. Commun.), 56, 12905-12908 (2020)
• Reinicke, J., Kitatani, R., Sedghi Masoud, S., Kawabata Galbraith, K., Yoshida, W., Igarashi, A., Nagasawa, K., Berger, G., Yanagihara, A., Nagai, F. A., Horgen, A. Isolation, Structure Determination, and Synthesis of Cyclic Tetraglutamic Acids from Box Jellyfish Species Alatina alata and Chironex yamaguchii. Molecules, 25, Article number:883, 2020
• Maleki, P., Mustafa, G., Gyawali, P., Budhathoki, J., Ma, Y., Nagasawa, K., Balci, H. Quantifying the impact of small molecule ligands on G-quadruplex stability against Bloom helicase. Nucleic Acids Research (Nucl. Acids Res.). 2019, 47 (20), 10744-10753, 2019.
• Gyawali, P., Gc, K., Ma, Y., Abeysirigunawardene, S., Nagasawa, K., Balci, B. Impact of Small Molecules on Intermolecular G-quadruplex Formation. Molecules. 24, Article number:1570. 2019.
• Jonchhe, S., Ghimire, C., Cui, Y., Sasaki, S., Park, S., Iida, K., Nagasawa, K., Sugiyama, H., Mao, H. Binding of a Telomestatin Derivative Changes Mechanical Anisotropy of Human Telomeric G-quadruplex, Angew. Chem., Int. Ed. 2019, 58, 877-881.
• Ma, Y., Iida, K., Sasaki, S., Hirokawa, T., Brahim, H., Phan, A.-T., Nagasawa, K. Synthesis and Telomeric G-quadruplex-stabilizing Ability of Macrocyclic Hexaoxazoles bearing Three Side Chains, Molecules 2019, 24, Article number:263. DOI: 10.3390/molecules24020263.
• Punnoose, A., Ma, Y., Enamul Hoque, M., Cui, Y., Sasaki, S., Huixin Guo, A., Nagasawa, K., Mao, H. Random Formation of G-Quadruplexes in the Full-Length Human Telomere Overhangs Leads to a Kinetic Folding Pattern with Targetable Vacant G-Tracts. Biochemistry, 57: 6946-6955, 2018.
• Mustafa, G., Chuang, C.-Y., Roy, A. W., Farhath, M. M., Pokhrel, N., Ma, Y., Nagasawa, K., Antony, E., Comstock, M. J., Basu, S., Balci, H. A Force Sensor that Converts Fluorescence Signal into Force Measurement Utilizing Short Looped DNA. Biosens Bioelectron. 2018, 121:34-40
• Sedghi, S. M., Yamaoki, Y., Ma, Y., Marchand, A., Richtia, A. F., Gabelica, V., Phan, A. T., Katahira, M., Nagasawa, K. Analysis of interaction between telomeric i-motif DNA and a cyclic tetraoxazole compound . ChemBioChem. 2018, 19:21:2268-2272, DOI: 10.1002/cbic.201800425