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【GIR公開セミナー】 Dr. Mauro Chinappi / ローマ・トルヴェルガタ大学(イタリア)

日時 2020.3.19(16:00~17:30)
会場 東京農工大学 小金井キャンパス 工学部13号館L1331
講演者・講演タイトル ◆Dr. Mauro Chinappi (Dipartimento di Ingegneria Industriale, Università di Roma Tor Vergata, Roma, Italia.)
  "Controlling nanoparticle transport and capture in nanopores: an open challenge for nanopore sensing and energy applications"

<要旨>
Nanopore based devices have been revolutionizing several key-applications such as biosensing, energy harvesting and water treatment. The interaction between dispersed nanoparticles (e.g. biological macromolecules or artificial nanometric solid objects) and the nanopores plays a crucial role in all cited technologies. In sensing applications [1],
selected molecules must be easily captured by the pore while the capture of unwanted molecules has to be avoided. Instead, in blue-energy harvesting and nanopore based water treatment systems, nanoparticles can clog the pore, dramatically reducing the system efficiency. Technological advancements are hindered by our lack of control and understanding of the coupling between hydrodynamics, electrokinetics and chemical effects that govern the nanoparticle motion at nanoscale.
An additional challenge is the nanometric scale of the system that makes the usual continuum modelling often unsuitable.
In this talk, I will present the main challenges related to capture and transport of nanoparticles through nanopores, the possible computational techniques to unravel transport regimes (ranging from atomistic models to continuum approaches [1])
and some preliminary results concerning two specific issues, namely, electroosmotic induced capture [2] and dielectrophoretic trapping (nanopore tweezers [3-4]).

<参考資料>
[1] Chinappi, M., & Cecconi, F. (2018). Protein sequencing via nanopore based devices: a nanofluidics perspective.
Journal of Physics: Condensed Matter
[2] Asandei, A., Schiopu, I., Chinappi, M., Seo, C. H., Park, Y., & Luchian, T. (2016). An Electroosmotic Trap
Against the Electrophoretic Force Near a Protein Nanopore Reveals Peptide Dynamics During Capture and
Translocation . ACS Applied Materials & Interfaces
[3] Chinappi, M, Luchian, T., Cecconi, T., Nanopore tweezers: Voltage-controlled trapping and releasing of analytes,
Phys. Rev. E
[4] Asandei, A., Rossini, A. E., Chinappi, M., Park, Y., & Luchian, T. (2017). Protein Nanopore-Based
Discrimination between Selected Neutral Amino Acids from Polypeptides. Langmuir
言語 英語
対象 どなたでも、ご聴講いただけます。
共催 グローバルイノベーション研究院 ライフサイエンス分野 篠原チーム
卓越大学院プログラム
開催概要
お問い合わせ窓口 グローバルイノベーション研究院 工学研究院 川野 竜司
e-mail: rjkawano (ここに@ を入れてください) cc.tuat.ac.jp

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